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Effects of estrogen deficiency on jaw bone

Research Scholar

Keiichiro Watanabe, assistant professor, Tokushima University (Japan)
Do-Gyoon Kim, faculty mentor


  • Hometown: Tokushima, Japan
  • Degrees received: DDS and PhD in oral sciences, Tokushima University, Japan.

What is the issue or problem addresses in your research?

More than half of the female population older than 50 years shows postmenopausal osteoporosis or low bone mass. Approximately one-third of postmenopausal women experience at least one osteoporotic vertebral or hip fracture in their lifetime that occurs spontaneously or from low-impact events. However, relatively few studies have been performed for jaw bone. Bone mass has a positive correlation with bone strength. However, it is indicated that bone mass alone cannot explain bone fragility.

What methodology did you use in your research?

We used twenty Sprague-Dawley female rats were given a bilateral ovariectomy (OVX, n=10) or a sham operation (n=10) at 6 months of age. After 2 months post-OVX, a mandible from each rat was dissected for a micro-computed tomography (CT). We obtained bone morphometric parameters using novel micro-CT based compartmentation of jaw bone. We also applied novel nanoindentation techniques to bone to analyze elastic, viscoelastic and plastic mechanical properties of bone at the tissue level.

What are the purpose/rationale and implications of your research?

To examine whether estrogen deficiency alters the bone mass, bone mineral density and tissue mineral density distribution and mechanical properties at the tissue level of jaw bone.