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Photochemical research and systematic in vitro study of the interaction mechanisms in novel trinuclear ruthenium complexes with DNA using different techniques

Research Scholar

Camila Silva, graduate student, Universidade de São Paulo (Brazil)
Claudia Turro, faculty mentor

Background

  • Hometown: Ribeirão Preto, Brazil
  • Degrees received: Master of Science in chemistry, Universidade de São Paulo, Brazil.

What is the issue or problem addresses in your research?

Considering the use of metallo drugs for cancer therapy some research indicates that the major challenge at the development of anticancer drugs is that most drugs do not present selectivity activity. In an attempt to improve the efficacy and overcome the side effects many compounds of numerous transition metals (platinum, ruthenium, copper) have been investigated over the last decades. These properties are attractive to design of new metal complexes that selectively bind to biomolecular target.

What methodology did you use in your research?

The clusters and ligands were synthesized according to literature methods. The DNA studies were performed by classical titration procedure. Viscosity experiments with DNA were performed using CT DNA. The "in vitro" cytotoxicity against tumor and non tumor cell line were evaluated by colorimetric method, MTT.

What are the purpose/rationale and implications of your research?

The main purpose is investigated the biological and chemical properties of the new class of trinuclear ruthenium clusters. This understanding will be relevant to advance and contribute to design of new metallo drugs structure that present selective biological target and consequently citotoxicity against cancer cell.