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Effect of SODm on IR-induced killing of lung cancer cells

Research Scholar

Yasmin Alzarie, assistant lecturer in pharmacology and toxicology department, National Organization of Drug Control and Research (Egypt)
Jay L. Zweier, Faculty Mentors

Background

  • Hometown: Cairo, Egypt
  • Degrees received:  Bachelor of Science, Master of Science in pharmaceutical science, Helwan University, Cairo.

What is the issue or problem addresses in your research?

Ionizing radiation (IR) is considered one of the most successful strategy to treat lung cancer, which remains the leading cause of mortality worldwide. However, IR-induced side effects hampers its clinical usefulness. Therefore, combinations of different pharmacological agents with IR have been in use to overcome it`s side effects and to enhance the efficacy.

What methodology did you use in your research?

XTT assay, clonogenic assay, Enzyme-linked immunosorbet assay (ELISA), Caspase-3 activity assay, Thioredoxin reductase activity, Western blot analysis, Electron Paramagnetic resonance (EPR).

What are the purpose/rationale and implications of your research?

Despite the fact that, radiation is one of the most successful strategy in cancer treatment,high doses of radiation needed for tumor therapy may probably exceed the tolerance of normal cells, which inevitably cause damage to normal cells at the same time.Thus we aim to develop new therapeutic regimen that my enhance the anti-cancer activity and lower the side effects of radiation through addition of MnSODm.