Ohio State Navbar

The Ohio State UniversityOffice of International Affairs

give a donation

Acute Systemic Responses to Periodontal Surgical Therapy

Research Scholar

Tamyris Oliveira, Dentistry (Brazil)
Dimitris N. Tatakis, Faculty Mentor


Tamyris Oliveira was born and raised in Alfenas, Minas Gerais, Brazil. She is a fourth year dental student at the School of Dentistry at Alfenas Federal University. She has been interested in research since the beginning of her dental education, and was developing her second project when the opportunity presented to participate in research in the Division of Periodontology, College of Dentistry at The Ohio State University. Following completion of her research at Ohio State, she will be going back to Brazil to finish her dental education and to continue her research activities. Her goal is to help improve oral health care.

What is the issue or problem addressed in your research?

Recent findings from the Centers for Disease Control and Prevention (CDC) indicate that 50% of American adults over age 30 have periodontitis, an inflammatory disease of infectious nature. Treatment of periodontitis, and approaches to replace teeth lost from periodontitis, may include specialized surgical procedures. Surgical procedures of any kind induce inevitable tissue trauma, which results in systemic responses. These responses include elevated levels of circulating cytokines, molecules that characterize and regulate the inflammatory and immune responses. Studies have identified specific cytokines as markers of the level of surgical stress experienced by patients. Despite the common occurrence of periodontitis and periodontal surgery, there are no studies that have examined the acute cytokine response in the serum of patients receiving periodontal therapy. The purpose of this study is to assess the systemic cytokine responses in patients undergoing periodontal surgical procedures.

What methodology did you use in your research?

Adult patients (18-56 years old; n=108) treatment planned to receive periodontal therapy at the Graduate Periodontology Clinic, College of Dentistry, The Ohio State University, will be asked to participate.  Subjects should be healthy overall, non-smokers, and scheduled to undergo one of a number of periodontal procedures (periodontal maintenance, scaling and root planing, osseous surgery, soft tissue grafting, crown lengthening, extraction and socket preservation, direct sinus lift, dental implant placement). Subjects will be asked to complete questionnaires and to provide five blood samples (immediately prior to the procedure; 1 hour, 1 day, 2 days, and 7 days after the procedure). Blood (~10 ml), collected by venipuncture, will be processed and stored until further analysis. The collected sera will be used to analyze pro-inflammatory, acute response, and anti-inflammatory cytokines, e.g., interleukin-6 (IL-6), IL-8, and HMGB1. Data will be analyzed statistically to determine the effect of time and procedure type.

What are the purpose/rationale and implications of your research?

The findings of this study could help minimize the surgical stress associated with periodontal surgery.